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KMID : 0391119950040020055
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Ulsan University Medical Journal
1995 Volume.4 No. 2 p.55 ~ p.61
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Chabge of Glutamic acid concentration in perilymph after sodium salicylate injection
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Abstract
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One of the unwanted side effects of salicylate is the ototoxicity presented with reversible hearing loss and tinnitus. But the exact pathogenesis of salicylate ototoxicity is not known yet. It has been postulated that salicylate affect the
neurotransmission between the hair cell of the cochlea and afferent neuron, where glutamic acid is considered s the mojor transmitter.
We measured the glutamic acid concentration in the perilymph from the inner ear of guinea pigs treated with sodium salicylate(460mg/kg, i.p.), using high performance liquid chromatography(HPLC) with the fluorescence detector, Glutamic acid
concentration
in the perilymyph was higher in the salicylate-treated guinea pigs compared to control animals treated with the vehicle. The glutamic acid concentration reached maximum 3 to 5 hours after the salicylate injection.
The results suggest that glutamic acid is involved in the salicylate ototoxicity.
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